Journal
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
Volume 8, Issue 4, Pages 424-431Publisher
XIA & HE PUBLISHING INC
DOI: 10.14218/JCTH.2020.00046
Keywords
Hepatitis B virus; Chronic HBV infection; Macrophage; Phenotype
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Funding
- Chinese Academy of Medical Sciences (CAMS) Initiative for Innovative Medicine [CAMS-2016-I2M-3-025, CAMS-2017-I2M-BR-15]
- National Key Research Development Program of China [2018YFE0107500]
- Science & Technology Department of Sichuan Province [2020YFH0070]
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Globally, hepatitis B virus (HBV) infection and its related liver diseases account for 780,000 deaths every year. Outcomes of HBV infection depend on the interaction between the virus and host immune system. It is becoming increasingly apparent that Kupffer cells (KCs), the largest population of resident and monocyte-derived macrophages in the liver, contribute to HBV infection in various aspects. These cells play an important role not only in the anti-HBV immunity including virus recognition, cytokine production to directly inhibit viral replication and recruitment and activation of other immune cells involved in virus clearance but also in HBV outcome and progression, such as persistent infection and development of end-stage liver diseases. Since liver macrophages play multiple roles in HBV infection, they are directly targeted by HBV to benefit its life cycle. In the present review, we briefly outline the current advances of research of macrophages, especially the studies of their phenotypes, in chronic HBV infection.
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