Journal
ACS APPLIED BIO MATERIALS
Volume 3, Issue 5, Pages 2666-2673Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c00181
Keywords
microfluidics; AS1411 aptamer; exosome; biomimetic nanoparticles; tumor targeting
Funding
- National Natural Science Foundation of China [91959101, 21904028, 21622503]
- Chinese Academy of Sciences [YJKYYQ20180055, ZDBS-LY-SLH025]
- Youth Innovation Promotion Association CAS [2016035]
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The coating of natural cellular or exosomal membranes (EMs) onto polymeric nanoparticles has become essential in extending the circulation half-time of nanoparticles by escaping from immune surveillance. Here we report on the surface modification of EM-coated poly(lactic-co-glycolic acid) (PLGA) nanoparticles by AS1411 aptamers (AS-EP) for improved tumor targeting. The combination of microfluidic sonication and cholesterol-modified aptamer functionalization allows for assembly of AS-EP within 10 min. The resulting AS-EP shows a prolonged in vivo circulation time benefiting from the natural properties of exosomes and exhibits high tumor targeting efficiency through specific binding of AS1411 aptamers to nucleolin on the membrane of tumor cells. Moreover, intravenous administration of AS-EP to mice will not result in abnormal pathology or hemolysis. This work opens up opportunities to fabricate and functionalize biomembrane-coated nanoparticles for targeted drug delivery applications.
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