Journal
ACS APPLIED BIO MATERIALS
Volume 3, Issue 8, Pages 5446-5453Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c00757
Keywords
tissue engineering; polyampholyte gel; scaffold; self-healing; hydrophilicity
Funding
- Ministry of Science and Technology (MOST) of the Republic of China (Taiwan) [MOST 106-2221-E-006-250, MOST 108-2218-E-006]
- Higher Education Sprout Project, Ministry of Education
Ask authors/readers for more resources
In this paper, we first demonstrate the control of the film pore size using neutral hydrophilic 2-hydroxyethyl methacrylate (HEMA) content. To improve the mechanical properties of a polyampholyte (PA), both HEMA and the cross-linker N,N'-methylenebisacrylamide (Bis-Am) were introduced into the PA chain. The predesigned copolymers showed great mechanical properties and optical behavior. The introduction of HEMA significantly increased the water content of the polymer, leading to the formation of porous structures in xerogels. The dynamic interaction between the positive and negative termini of the PA endowed the hydrogels with self-healing ability. The synthesized chemically cross-linked PA gels showed high stability in saline solution. The biocompatibility of the PA gels was confirmed using a cytotoxicity test of cells attached to the synthesized PA-X-2 and PA/HEMA-90/10-X-0.5. The results of this investigation indicate that the synthesized PA gels are applicable as a polymeric scaffold for cell culture.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available