Journal
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
Volume 3, Issue 5, Pages 1032-1034Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsptsci.0c00136
Keywords
COVID-19; Hb-HO-1 system; iron homeostasis; iron chelation therapy; CO therapy
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Acute respiratory distress syndrome (ARDS) is one of the critical stages of COVID-19, leading to lung injury and hemolysis. Dysfunctional hemoglobin (Hb) suffers low-level oxygenation, overloaded iron, and down-regulation of hemeoxygenase-1 (HO-1), representing potential therapeutic interventions. This Viewpoint outlines the Hb-HO-1 system as a host-cell target, and proposes possible therapies, including iron chelation and CO therapies, against COVID-19 with ARDS.
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