Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 12, Issue 46, Pages 51236-51248Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c14805
Keywords
catecholamine; bioinspired lubrication; ROS scavenging osteoarthritis; articular cartilage
Funding
- National Natural Science Foundation of China [52022043, 51675296]
- Tsinghua University-Peking Union Medical College Hospital Initiative Scientific Research Program [20191080593]
- China Postdoctoral Science Foundation [2019M660620]
- Foshan-Tsinghua Innovation Special Fund (FTISF)
- Research Fund of State Key Laboratory of Tribology, Tsinghua University, China [SKLT2020C11]
- Ng Teng Fong Charitable Foundation [202-276-132-13]
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Osteoarthritis (OA) is a chronic joint disease and its progression and pathogenesis are highly associated with the significant increase of joint friction and overproduction of reactive oxygen species (ROS) in inflammation. Combination of ROS elimination and lubrication enhancement may provide a novel strategy for the treatment of OA. In the present study, a pure biomaterial and nondrug system P(DMA-co-MPC), synthesized via free radical copolymerization, was designed and developed for the first time using 2-methacryloxyethyl phosphorylcholine (MPC) as a bioinspired lubricant and N-(3,4-dihydroxyphenethyl)methacrylamide (DMA) as an ROS scavenger. Our results showed that the P(DMA-co-MPC) aggregates could efficiently eliminate the ROS radicals and provide good lubrication property by adjusting the molar ratio of DMA and MPC in the copolymer. It is attributed to the antioxidant function of the hydroquinone moiety in DMA and the hydration lubrication effect of the zwitterionic phosphocholine group in MPC. Furthermore, the in vitro experiments demonstrated that the P(DMA-co-MPC) showed good biocompatibility with MC3T3-E1 cells and intracellular antiinflammatory property by inhibiting the production of ROS and regulating the expression levels of pro-inflammatory cytokines, painrelated gene, anabolic genes, and catabolic genes. In conclusion, the drug-free P(DMA-co-MPC) aggregates developed herein can achieve dual functions of lubrication enhancement and anti-inflammatory effect and thus they may be representative as promising candidates for the treatment of OA.
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