Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 142, Issue 46, Pages 19487-19492Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.0c10122
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Funding
- National Science Foundation of China [21772004, 21632002, 21871012]
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A concise chemical synthesis of (+)-haperforin G in 20 steps from commercially available starting materials is achieved with the integration of the Co-catalyzed intramolecular Pauson-Khand reaction for the stereoselective construction of cyclopentanone bearing an all-carbon quaternary stereogenic center at the bridge-head position and the light-initiated photocatalysis for convergent and asymmetric cross-coupling of the unstabilized C(sp(3))-radical with an enone. The developed chemistry paves the way to synthesizing structurally diverse analogs of haperforin G (6).
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