Journal
ACS NANO
Volume 14, Issue 11, Pages 14919-14928Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c04370
Keywords
AgBiS2; hollow nanostructures; nanozyme; photothermal therapy; photoacoustic imaging
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Funding
- National Natural Science Foundation of China [21471043, 52003005]
- Grants for Scientific Research of BSKY from Anhui Medical University [XJ201933, XJ201906, XJ201905, XJ201909]
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Specific cytotoxicity for catalytic nanomedicine triggered by the tumor microenvironment (TME) has attracted increasing interest. In this work, we prepared AgBiS2 hollow nanospheres with narrow bandgaps via rapid precipitation in a weakly polar solvent, which lowered the intrinsic energy gap for the active production of highly reactive hydroxyl radicals ((OH)-O-center dot), especially in the TME. The as-prepared AgBiS2 hollow nanospheres exhibited enhanced optical absorption and high photothermal conversion efficiency (44.2%). In addition, the hollow structured AgBiS2 nanospheres were found to have a peroxidase-mimicking feature to induce cancer cell-specific cytotoxicity while exhibiting negligible cytotoxicity toward normal cells, which might be attributed to the efficient production of highly reactive (OH)-O-center dot originating from the overexpression H2O2 in the TME caused by surface catalysis. In particular, the cancer cell-specific cytotoxicity of the nanospheres was greatly enhanced both in vitro and in vivo upon irradiation with a near-infrared (NIR) laser (808 nm). The above-mentioned features of the hollow structured AgBiS2 will make it a promising candidate for tumor therapy.
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