Serum salusin-β in relation to atherosclerosis and ventricular dysfunction in patients with type 2 diabetes mellitus

Background and aims: Salusin-beta is a newly defined biomarker that plays a role in atherogenesis and in homeostasis. The study aimed to assess serum salusin-beta level in relation to atherosclerosis and ventricular dysfunction in type 2 diabetes mellitus (T2DM) patients. Methods: Sixty T2DM patients and twenty-five age-matched healthy controls were included. Serum salusin-beta was determined by ELISA. Echocardiography and carotid ultrasonography were carried out for all individuals. Results: Serum salusin-beta level was significantly elevated in patients with T2DM than in controls (P < 0.001). It was positively correlated with obesity parameters, insulin resistance index (r = 0.280,P < 0.001), atherogenic dyslipidemia and with carotid intima media thickness (CIMT) (r = 0.411, P < 0.001). Echocardiographic findings showed a positive correlation between salusin-beta and left ventricular hypertrophy (LVH) parameters and a negative correlation with left ventricular (LV) diastolic and systolic functions. Regression analysis showed that serum salusin-beta level was a significant predictor of diastolic dysfunction. Conclusion: Serum salusin-beta may be associated with atherosclerosis and LV dysfunction in T2DM. (C) 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.