Journal
NON-CODING RNA RESEARCH
Volume 5, Issue 4, Pages 178-184Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.ncrna.2020.09.003
Keywords
Long noncoding RNA; LincRNA; CircRNA; CRISPR; Phenotype; Physiological function
Categories
Funding
- National Natural Science Foundation of China [31725016, 31930019, 91940303, 31900442]
- National Key R&D Program of China [2019YFA0802600, 2018YFC1004500]
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The physiological processes of cells and organisms are regulated by various biological macromolecules, including long-noncoding RNAs (lncRNAs), which cannot be translated into protein and are different from small-noncoding RNAs on their length. In animals, lncRNAs are involved in development, metabolism, reproduction, aging and other life events by cis or trans effects. For many functional lncRNAs, there is growing evidence that they play different roles on cellular level and organismal level. On the other hand, many annotated lncRNAs are not essential and could be transcription noises. In this minireview, we investigate the physiological function of lncRNAs in cells and focus on their functions and functional mechanisms on the organismal level. The studies on lncRNAs using different classic animal models such as worms and flies are summarized and discussed in this article.
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