Journal
ACS APPLIED BIO MATERIALS
Volume 3, Issue 4, Pages 2516-2521Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c00212
Keywords
fluorogenic sensors; DOPA 4,5-dioxygenase; green synthesis; betaxanthin; Cu2+
Funding
- Ministry of Science and Technology of Taiwan [107-2113-M-003-013-MY3]
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In this study, we developed a simple and economical method for the green synthesis of Cu2+ sensors based on betaxanthin pigments. Aminoisophthalic acidbetaxanthin was synthesized by coupling 2-aminoisophthalic acid and betalamic acid produced from DOPA-extradiol-4,5-dioxygenase in situ and in vitro. The resulting 2-aminoterephthalic acidbetaxanthin (2-AIPABX) presented a satisfying fluorescence quantum yield in water and a high degree of selectivity for Cu2+ over interfering metal ions. The bioproduction process of 2-AIPABX was scaled up from test tubes to 1 L-flasks, indicating the robustness and reproducibility of this method. Additionally, we successfully incorporated 2-AIPABX into paper-based analytical devices to facilitate simple, inexpensive, and portable setup with lower sample consumption for onsite monitoring of environmental and biological samples.
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