Journal
EPILEPSY & BEHAVIOR REPORTS
Volume 14, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ebr.2020.100390
Keywords
Drug-resistant epilepsy; Seizure freedom; Chronic subthreshold cortical stimulation; Chronic subthreshold stimulation; Neuromodulation; Anterior thalamic nucleus
Categories
Funding
- NIHNINDS [K23NS112339]
- NIH NINDS [R01NS92882]
- American Epilepsy Society Research & Training Fellowship for Clinicians
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Neuromodulation strategies that target the epileptogenic network are options for treating focal drug-resistant epilepsy. These brain stimulation approaches include responsive neurostimulation and more recently, chronic subthreshold stimulation. Long-term seizure freedom with neuromodulation is uncommon. Seizure control typically requires ongoing froms of electrical stimulation. Here, we present the case of a patient implanted with three cortical electrodes targeting the inferior frontal lobe, insula, and one subcortical electrode targeting the ipsilateral anterior thalamic nucleus. This patient received continuous subthreshold electrical stimulation to the frontal electrodes for 7 months, at which time stimulation was inadvertently stopped. He has now been free of seizures for 42 months. This case suggests the possibility that neuromodulation can alter epileptogenic networks and lead to seizure freedom without ongoing electrical stimulation. (C) 2020 The Authors. Published by Elsevier Inc.
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