Journal
HYPERTENSION IN PREGNANCY
Volume 36, Issue 4, Pages 295-301Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10641955.2017.1385794
Keywords
Fetal cell-free DNA; total cell-free DNA; soluble human leucocyte antigen; pre-eclampsia; gestational hypertension
Funding
- South African National Research Foundation [91544]
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Objective: Quantification of circulating fetal and total cell-free DNA (cfDNA) and soluble human leucocyte antigen (HLAG) in gestational hypertension and pre-eclampsia.Methods: Serum cfDNA were quantified in controls, pre-eclamptics, and gestational hypertensive patients using real-time qPCR. Soluble HLAG was measured by enzyme-linked immune-sorbent assay.Results: Serum fetal and total cfDNA levels were higher in pre-eclampsia compared with the controls and gestational hypertensives (p<0.001), more so in severe compared with mild-to-moderate pre-eclampsia (p<0.05). Soluble HLAG levels were lower in pre-eclamptics than controls and gestational hypertension (p<0.05).Conclusion: Circulating fetal and total cfDNA were increased, while soluble HLAG was decreased in pre-eclampsia.
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