Related references
Note: Only part of the references are listed.Neurotoxic reactive astrocytes are induced by activated microglia
Shane A. Liddelow et al.
NATURE (2017)
Soluble Oligomers of PolyQ-Expanded Huntingtin Target a Multiplicity of Key Cellular Factors
Yujin E. Kim et al.
MOLECULAR CELL (2016)
Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model
Huimin Wang et al.
MOLECULAR MEDICINE REPORTS (2016)
A complement-microglial axis drives synapse loss during virus-induced memory impairment
Michael J. Vasek et al.
NATURE (2016)
Dietary Luteolin Reduces Proinflammatory Microglia in the Brain of Senescent Mice
Michael D. Burton et al.
REJUVENATION RESEARCH (2016)
Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System
Violeta Chitu et al.
TRENDS IN NEUROSCIENCES (2016)
Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract
Koning Shen et al.
ELIFE (2016)
Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on threonine 3 and regulation by IKKβ
Maria Blaire Bustamante et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
Increased central microglial activation associated with peripheral cytokine levels in premanifest Huntington's disease gene carriers
Marios Politis et al.
NEUROBIOLOGY OF DISEASE (2015)
Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6
I. Tsilioni et al.
TRANSLATIONAL PSYCHIATRY (2015)
HTT-lowering reverses Huntington's disease immune dysfunction caused by NFκB pathway dysregulation
Ulrike Traeger et al.
BRAIN (2014)
Targeting IL-34 in chronic inflammation
Emma L. Masteller et al.
DRUG DISCOVERY TODAY (2014)
Live cell imaging and biophotonic methods reveal two types of mutant huntingtin inclusions
Nicholas S. Caron et al.
HUMAN MOLECULAR GENETICS (2014)
Luteolin Reduces Alzheimer's Disease Pathologies Induced by Traumatic Brain Injury
Darrell Sawmiller et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)
Procaspase-3 regulates fibronectin secretion and influences adhesion, migration and survival independently of catalytic function
Matthew Brentnall et al.
JOURNAL OF CELL SCIENCE (2014)
Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors
Andrea Crotti et al.
NATURE NEUROSCIENCE (2014)
Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
Marco Prinz et al.
NATURE REVIEWS NEUROSCIENCE (2014)
Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders
Matthew P. Parsons et al.
NEURON (2014)
Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor
Christopher N. Parkhurst et al.
CELL (2013)
A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease
Han-Yun Hsiao et al.
HUMAN MOLECULAR GENETICS (2013)
Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival
Jian Luo et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2013)
Regulation of Microglial Proliferation during Chronic Neurodegeneration
Diego Gomez-Nicola et al.
JOURNAL OF NEUROSCIENCE (2013)
Sustained, neuron-specific IKK/NF-κB activation generates a selective neuroinflammatory response promoting local neurodegeneration with aging
Ayesha Maqbool et al.
MOLECULAR NEURODEGENERATION (2013)
Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH
Guo Zhang et al.
NATURE (2013)
Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease
Kirupa Sathasivam et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Human IL-34 and CSF-1 Establish Structurally Similar Extracellular Assemblies with Their Common Hematopoietic Receptor
Jan Felix et al.
STRUCTURE (2013)
Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress
Julia Leitman et al.
NATURE COMMUNICATIONS (2013)
Protein aggregates in Huntington's disease
Montserrat Arrasate et al.
EXPERIMENTAL NEUROLOGY (2012)
Stroma-Derived Interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia
Melanie Greter et al.
IMMUNITY (2012)
IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia
Yaming Wang et al.
NATURE IMMUNOLOGY (2012)
Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons
Andrew D. Kraft et al.
NEUROBIOLOGY OF AGING (2012)
Interleukin-34 Selectively Enhances the Neuroprotective Effects of Microglia to Attenuate Oligomeric Amyloid-β Neurotoxicity
Tetsuya Mizuno et al.
AMERICAN JOURNAL OF PATHOLOGY (2011)
Microglial activation in regions related to cognitive function predicts disease onset in Huntington's Disease: A multimodal imaging study
Marios Politis et al.
HUMAN BRAIN MAPPING (2011)
Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assay
Peter H. p Reinhart et al.
NEUROBIOLOGY OF DISEASE (2011)
The role of IκB kinase complex in the neurobiology of Huntington's disease
Ali Khoshnan et al.
NEUROBIOLOGY OF DISEASE (2011)
Cleavage at the 586 Amino Acid Caspase-6 Site in Mutant huntingtin Influences Caspase-6 Activation In Vivo
Rona K. Graham et al.
JOURNAL OF NEUROSCIENCE (2010)
Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease
Chiara Zuccato et al.
PHYSIOLOGICAL REVIEWS (2010)
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome
Leslie Michels Thompson et al.
JOURNAL OF CELL BIOLOGY (2009)
IKKα and IKKβ Regulation of DNA Damage-Induced Cleavage of Huntingtin
Ali Khoshnan et al.
PLOS ONE (2009)
The NF-κB-independent functions of IKK subunits in immunity and cancer
Alain Chariot
TRENDS IN CELL BIOLOGY (2009)
A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease
Maria Bjorkqvist et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
Microglial activation in presymptomatic Huntington's disease gene carriers
Yen F. Tai et al.
BRAIN (2007)
Microglial activation correlates with severity in Huntington disease - A clinical and PET study
N. Pavese et al.
NEUROLOGY (2006)
Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of I kappa B kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell proliferation
PL Podolin et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Activation of the IκB kinase complex and nuclear factor-κB contributes to mutant Huntingtin neurotoxicity
A Khoshnan et al.
JOURNAL OF NEUROSCIENCE (2004)
Effect of mutant α-synuclein on dopamine homeostasis in a new human mesencephalic cell line
J Lotharius et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis
YJ Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
New anti-huntingtin monoclonal antibodies: Implications for huntingtin conformation and its binding proteins
J Ko et al.
BRAIN RESEARCH BULLETIN (2001)