Journal
HUMAN IMMUNOLOGY
Volume 78, Issue 2, Pages 179-184Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2016.10.018
Keywords
Psoriasis; HIV; Genetics; Immunogenetics; MHC; Viral control; Viral load; Primary infection
Categories
Funding
- NIH [R01AR065174, U01A1119125]
- Creative and Novel Ideas in HIV Research Program (CNIHR) [P30 AI027767-24]
- National Institutes of Allergies and Infectious Diseases
- International AIDS Society
- UCSF/Gladstone Institute of Virology & Immunology CFAR [P30 AI027763]
- CFAR Network of Integrated Systems [R24 AI067039]
- National Institute of Allergy and Infectious Disease (NIAID) [AI071713]
- Center for Inherited Disease Research (CIDR) [1 X01 HG005275-01A1]
- CIDR through National Institutes of Health [HHSN268200782096C]
- NIDA [R01DA026141, R01DA004212, U01DA006908, R01DA009532]
- San Francisco Department of Public Health
- SAMHSA
- HRSA
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Human evolution has resulted in selection for genetic polymorphisms beneficial in the defense against pathogens. However, such polymorphisms may have the potential to heighten the risk of autoimmune disease. Here, we investigated whether psoriasis-associated single nucleotide polymorphisms influence host control of HIV-1 infection. We studied psoriasis and viral immune response variants in three HIV-positive cohorts: (1) HIV-1 controllers and non-controllers in the Study of the Consequences of the Protease Inhibitor Era (SCOPE) cohort (n = 366), (2) Individuals with primary HIV infection in the Options cohort (n = 675), and (3) HIV-positive injection drug users from the Urban Health Study (UHS) (n = 987). We found a strong association of two psoriasis MHC variants, rs9264942 and rs3021366, with both HIV-1 controller status and viral load, and identified another Class III MHC variant rs9368699 to be strongly associated with viral load. A number of genetic variants outside the MHC (SOX5, TLR9, SDC4, PROX1, IL12B, TLR4, MBL-2, TYK2, IFIH1) demonstrated nominal significance. Overall, our data suggest that several psoriasis variants within the MHC have a robust impact on HIV-1 control, while variants outside the MHC require further investigation. (C) 2016 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
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