Journal
HUMAN BRAIN MAPPING
Volume 38, Issue 6, Pages 3069-3080Publisher
WILEY
DOI: 10.1002/hbm.23574
Keywords
dynamic connectivity; decoding; fMRI; global efficiency; brain networks; connectomics; vision; faces; motion
Funding
- Australian Research Council (ARC) Australian Laureate Fellowship [FL110100103]
- ARC Centre of Excellence for Integrative Brain Function [CE140100007]
- Australian National Health Medical Research Council [APP1099082, APP1047648, APP1110975]
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Functional magnetic resonance imaging (fMRI) studies have shown that neural activity fluctuates spontaneously between different states of global synchronization over a timescale of several seconds. Such fluctuations generate transient states of high and low correlation across distributed cortical areas. It has been hypothesized that such fluctuations in global efficiency might alter patterns of activity in local neuronal populations elicited by changes in incoming sensory stimuli. To test this prediction, we used a linear decoder to discriminate patterns of neural activity elicited by face and motion stimuli presented periodically while participants underwent time-resolved fMRI. As predicted, decoding was reliably higher during states of high global efficiency than during states of low efficiency, and this difference was evident across both visual and nonvisual cortical regions. The results indicate that slow fluctuations in global network efficiency are associated with variations in the pattern of activity across widespread cortical regions responsible for representing distinct categories of visual stimulus. More broadly, the findings highlight the importance of understanding the impact of global fluctuations in functional connectivity on specialized, stimulus driven neural processes. (C) 2017 Wiley Periodicals, Inc.
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