Journal
HUMAN BRAIN MAPPING
Volume 39, Issue 3, Pages 1163-1174Publisher
WILEY
DOI: 10.1002/hbm.23907
Keywords
amygdala; diffusion tensor imaging; dystonia; fMRI; motion perception
Funding
- National Institute of Neurological Disorders and Stroke [R01 NS072514]
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In healthy subjects, brain activation in motor regions is greater during the visual perception of natural target motion, which complies with the two-thirds power law, than of unnatural motion, which does not. It is unknown whether motion perception is normally mediated by a specific network that can be altered in the setting of disease. We used block-design functional magnetic resonance imaging and covariance analysis to identify normal network topographies activated in response to natural versus unnatural motion. A visual motion perception-related pattern (VPRP) was identified in 12 healthy subjects, characterized by covarying activation responses in the inferior parietal lobule, frontal operculum, lateral occipitotemporal cortex, amygdala, and cerebellum (Crus I). Selective VPRP activation during natural motion was confirmed in 12 testing scans from healthy subjects. Consistent network activation was not seen, however, in 29 patients with dystonia, a neurodevelopmental disorder in which motion perception pathways may be involved. Using diffusion tractography, we evaluated the integrity of anatomical connections between the major VPRP nodes. Indeed, fiber counts in these pathways were substantially reduced in the dystonia subjects. In aggregate, the findings associate normal motion perception with a discrete brain network which can be disrupted under pathological conditions.
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