Journal
CRITICAL REVIEWS IN MICROBIOLOGY
Volume 42, Issue 5, Pages 677-695Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/1040841X.2015.1010139
Keywords
Actin-based motility; actin cytoskeleton; cofilin; entry; pathogen infection
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Funding
- National Natural Science Foundation of China [81274170]
- Major Platform Project Funds of Administration of Ocean and Fisheries of Guangdong, China [GD2012-D01-002]
- Research of Quality Control for Sulfur-Fumigated Chinese Materia Medica [SGLH20120926161415784]
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Actin-depolymerizing factor (ADF)/cofilin proteins are key players in controlling the temporal and spatial extent of actin dynamics, which is crucial for mediating host-pathogen interactions. Pathogenic microbes have evolved molecular mechanisms to manipulate cofilin activity to subvert the actin cytoskeletal system in host cells, promoting their internalization into the target cells, modifying the replication niche and facilitating their intracellular and intercellular dissemination. The study of how these pathogens exploit cofilin pathways is crucial for understanding infectious disease and providing potential targets for drug therapies.
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