Journal
CRITICAL REVIEWS IN IMMUNOLOGY
Volume 35, Issue 1, Pages 77-84Publisher
BEGELL HOUSE INC
DOI: 10.1615/CritRevImmunol.2015012127
Keywords
lipocalin-2; astrocytes; neuroinflammation; central nervous system; chemokine; polarization
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Funding
- National Research Foundation (NRF) - Korean Ministry of Education, Science, and Technology (MEST) [2008-0062282, 2012R1A2A2A02046812]
- Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [A111345, HI14C3331]
- Establishment and Operation of the Korea Brain Research Institute (KBRI) Basic Research Program of the Ministry of Science, ICT & Future Planning [2231-415]
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Lipocalin-2 (LCN2), a secretory protein, regulates diverse cellular processes such as cell death/survival, cell migration/invasion, cell differentiation, iron delivery, inflammation, insulin resistance, and tissue regeneration. Recently, we reported that LCN2 is secreted by brain astrocytes under inflammatory conditions and that it promotes apoptosis, morphological changes, and migration in astrocytes both in vitro and in vivo. Activated astrocytes release LCN2 not only to induce the morphological transformation associated with reactive astrocytosis, but also to promote their own death. Under inflammatory conditions, activated astrocytes also show functional dichotomy similar to the M1/M2 phenotypes of microglia and macrophages. LCN2 is thought to be a chemokine inducer and an autocrine promoter of the classical proinflammatory activation of astrocytes. This article summarizes the current knowledge regarding the role of astrocyte-derived LCN2 as a proinflammatory mediator in the central nervous system and discusses LCN2's role in neuroinflammatory disorders.
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