Journal
HETEROCYCLES
Volume 94, Issue 12, Pages 2179-2207Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/REV-17-869
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Funding
- Platform Project for Supporting Drug Discovery and Life Science Research - Japan Agency for Medical Research and Development (AMED), JSPS KAKENHI [17K19112, 15H00911]
- Tohoku University Center for Gender Equality Promotion (TUMUG)
- Morinomiyako Project for Empowering Women in Research
- Grants-in-Aid for Scientific Research [17K19112, 15H00911] Funding Source: KAKEN
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Unsymmetric HetAr-X-HetAr' compounds have flexible and chiral structures, and are expected to exhibit various biological activities by interacting with proteins and nucleic acids. Unsymmetric HetAr-X-HetAr' compounds were efficiently synthesized by rhodium-catalyzed heteroaryl exchange reactions, which involved equilibrium control by judicious design of organic heteroaryl reagents. By using this method, unsymmetric HetAr-O-HetAr', HetAr-S-HetAr', and HetAr-CH(2-)HetAr' compounds as well as HetAr-F compounds were obtained from heteroaryl aryl ethers and various heteroaryl reagents. The rhodium-catalyzed synthesis has a broad applicability, which gives novel unsymmetric HetAr-X-HetAr' compounds containing five- and six-membered heteroarenes.
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