4.0 Article

A high-efficient method for the amidation of carboxylic acids promoted by triphenylphosphine oxide and oxalyl chloride

Journal

HETEROATOM CHEMISTRY
Volume 28, Issue 2, Pages -

Publisher

WILEY-HINDAWI
DOI: 10.1002/hc.21364

Keywords

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Funding

  1. Shanghai Alliance Program [LM 201666]
  2. Shanghai Students' Science and Technology Innovation Activities Key Projects [SH 2016001]
  3. Capacity-building Projects in Shanghai Local Universities [15120503700]

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A effective amidation reaction of carboxylic acids with various amines promoted by triphenylphosphine oxide and oxalyl chloride under mild and neutral conditions has been developed. The feature of this procedure was the using and recycling of triphenylphosphine oxide at room temperature in 0.5 h. Furthermore a plausible mechanism also be deduced with the help of P-31 NMR spectroscopy.

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