Journal
ONCOIMMUNOLOGY
Volume 9, Issue 1, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2020.1809936
Keywords
Autophagy; VPS34; cold; hot tumors; proinflammatory cytokines; CCL5; CXCL10; immune landscape; NK cells; T CD8 lymphocytes; cancer immunotherapy; anti-PD-1; PD-L1; melanoma; colon cancer
Categories
Funding
- Luxembourg National Research Fund [C18/BM/12670304/COMBATIC]
- Action LIONS Vaincre le Cancer Luxembourg
- Fondation Cancer Luxembourg [FC/2018/06]
- Kriibskrank Kanner Foundation [2016-08-15]
- Janssen Cilag Pharma
- Roche pharma
Ask authors/readers for more resources
Cancer immunotherapy based on anti-PD-1/PD-L1 blockade is particularly effective in responding to patients with hot tumors. These tumors are characterized by the accumulation of proinflammatory cytokines and T cell infiltration. In our recent report published inScience Advances, we demonstrate that targeting the autophagy-related protein Vps34 switched cold immune desert tumors into hot inflamed immune-infiltrated tumors and enhanced the efficacy of anti-PD-1/PD-L1. Our study provides the preclinical rationale to set up combination immunotherapy clinical trials using selective Vps34 inhibitors and immune checkpoint blockers in melanoma and CRC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available