Journal
HEPATOLOGY INTERNATIONAL
Volume 11, Issue 6, Pages 481-484Publisher
SPRINGER
DOI: 10.1007/s12072-017-9831-0
Keywords
Hepatitis B virus; Transmission; Viral factor
Categories
Funding
- National Taiwan University Hospital
- Ministry of Science and Technology
- Ministry of Health and Welfare, Executive Yuan, Taiwan
- Liver Diseases Prevention and Treatment Research Foundation, Taiwan
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Chronic hepatitis B virus (HBV) infection due to perinatal mother-to-infant transmission (MTIT) remains a serious global health problem. Despite passive-active immunoprophylaxis using hepatitis B vaccination with or without hepatitis B immunoglobulin (HBIg), up to 8-10% of newborns still acquire HBV infection. Understanding the mechanisms of MTIT is essential for the interruption of HBV transmission. There are three possible routes of transmission: intrauterine transmission, transmission during delivery (intrapartum) and postnatal transmission through close contact or breast milk (postpartum). Overall, positivity for hepatitis B e antigen (HBeAg) and the high viral load of the mothers are the two most important risk factors related to MTIT of HBV. This article briefly reviews the viral factors related to MTIT of HBV and discusses the issues that warrant further investigation.
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