Journal
INTERNATIONAL JOURNAL OF HYPERTHERMIA
Volume 37, Issue 1, Pages 1116-1130Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/02656736.2020.1817575
Keywords
MRgHIFU; sonosensitizers; micro-droplets; perfused model; thermal deposition
Funding
- European Union's Horizon 2020 research and innovation programme under the Sklodowska-Curie grant [813766]
- Swiss National Science Foundation [CR3313_143980]
Ask authors/readers for more resources
Background High intensity focused ultrasound (HIFU) is clinically accepted for the treatment of solid tumors but remains challenging in highly perfused tissue due to the heat sink effect. Endovascular liquid-core sonosensitizers have been previously suggested to enhance the thermal energy deposition at the focal area and to lower the near-/far-field heating. We are investigating the therapeutic potential of PFOB-FTAC micro-droplets in a perfused tissue-mimicking model and postmortem excised organs. Method A custom-madein vitroperfused tissue-mimicking model, freshly excised pig kidneys (n = 3) and liver (n = 1) were perfused and subjected to focused ultrasound generated by an MR-compatible HIFU transducer. PFOB-FTAC sonosensitizers were injected in the perfusion fluid up to 0.235% v/v ratio. Targeting and on-line PRFS thermometry were performed on a 3 T MR scanner. Assessment of the fluid perfusion was performed with pulsed color Dopplerin vitroand with dynamic contrast-enhanced (DCE)-MRI in excised organs. Results Ourin vitromodel of perfused tissue demonstrated re-usability. Sonosensitizer concentration and perfusion rate were tunablein situ. Differential heating under equivalent HIFU sonications demonstrated a dramatic improvement in the thermal deposition due to the sonosensitizers activity. Typically, the energy deposition was multiplied by a factor between 2.5 and 3 in perfused organs after the administration of micro-droplets, while DCE-MRI indicated an effective perfusion. Conclusion The current PFOB-FTAC micro-droplet sonosensitizers provided a large and sustained enhancement of the HIFU thermal deposition at the focal area, suggesting solutions for less technological constraints, lower risk for the near-/far- field heating. We also report a suitable experimental model for other MRgHIFU studies
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available