Journal
REVIEWS IN ANALYTICAL CHEMISTRY
Volume 39, Issue 1, Pages 231-246Publisher
DE GRUYTER POLAND SP Z O O
DOI: 10.1515/revac-2020-0118
Keywords
metal ions sensing; fluorescent detection; fluorescent imaging; organic dyes
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Funding
- Beijing Natural Science Foundation [2202043]
- National Natural Science Foundation of China [51903014, 21908005, 21774007]
- China Postdoctoral Science Foundation [2020T130044]
- Fundamental Research Funds for the Central Universities [ZY2024, PT1811]
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Metal ions are widely present in biological systems and participate in many critical biochemical processes such as material transportation, energy conversion, information transmission and metabolic regulation, making them indispensable substance in our body. They can cause health problems when deficiency or excess occurs. To understand various metabolic processes and facilitate diseases diagnosis, it is very important to measure the content and monitor the distribution of metal ions in individual cells, tissues and whole organisms. Among the various methods for metal ion detection, fluorescent sensors with organic dyes have attracted tremendous attention due to many advantages such as high fluorescence quantum yield, facile modification approaches and biocompatibility in addition to operation ease, high sensitivity, fast detection speed, and real-time detection. This review summarizes the recent progress on the detection and imaging of the metal ions in biological systems including Na+, K+, Ca2+, Mg2+, Fe2+/Fe3+, Zn2+, and Cu2+ provides an opinion on remaining challenges to be addressed in this field.
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