Journal
CELL REPORTS MEDICINE
Volume 1, Issue 8, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.xcrm.2020.100132
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Funding
- Diabetes Research Center (DRC) [NIHP30 DK063720]
- Doris Duke Clinician-Scientist Development Award [2017070]
- NIH [5K08AR68409]
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Lymphocytes in barrier tissues play critical roles in host defense and homeostasis. These cells take up residence in tissues during defined developmental windows, when they may demonstrate distinct phenotypes and functions. Here, we utilized mass and flow cytometry to elucidate early features of human skin immunity. Although most conventional alpha beta T (Tconv) cells in fetal skin have a naive, proliferative phenotype, a subset of CD4(+) Tconv and CD8(+) cells demonstrate memory-like features and a propensity for interferon (IFN)gamma production. Skin regulatory T cells dynamically accumulate over the second trimester in temporal and regional association with hair follicle development. These fetal skin regulatory T cells (Tregs) demonstrate an effector memory phenotype while differing from their adult counterparts in expression of key effector molecules. Thus, we identify features of prenatal skin lymphocytes that may have key implications for understanding antigen and allergen encounters in utero and in infancy.
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