Journal
HEART AND VESSELS
Volume 32, Issue 11, Pages 1314-1319Publisher
SPRINGER
DOI: 10.1007/s00380-017-1003-6
Keywords
Inflammation; Periodontal disease; Peripheral artery disease
Funding
- JSPS [JP25870198, JP15K20616, JP16H05824]
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Mitsui Life Insurance Research Foundation
- Mitsui Sumitomo Marine Welfare Research Foundation
- Geriatric Dental Research Foundation
- Human Health Future Research Foundation
- St. Luke's Hospital Research Foundation
- Health Management Foundation
- Taiyo Life Insurance Research Foundation
- The 8020 Promotion Foundation
- Terumo Science Foundation
- Pfizer Health Research Foundation
- General Health Promotion Foundation
- Suzuken Memorial Foundation
- Health Science Center Foundation
- Kobayashi International Scholarship Foundation
- Banyu Life Science Foundation International
- Japan Heart Foundation
- Astellas Grant for Research on Atherosclerosis Update
- Hakujikai Institute of Gerontology Foundation
- Grants-in-Aid for Scientific Research [17K08585, 16K15199, 17K19673, 15H04806, 17K17347, 16H05824] Funding Source: KAKEN
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Peripheral arterial disease (PAD) is a common manifestation of arterial stenosis of the extremity that reduces arterial flow. While patients with periodontitis are at a high risk of PAD, little causal information has been provided to date. To clarify the relationship, we conducted this cross-sectional study. The oral condition of patients with or without PAD, who attended Tokyo Medical and Dental University Hospital, was evaluated. Blood examinations and dental clinical measurements, including number of teeth, probing pocket depth (PPD), bleeding on probing (BOP) and clinical attachment level (CAL) were performed. Chi-square test was performed to compare gender, smoker rate, prevalence of DM, hypertension and dyslipidemia and edentulous rate. Wilcoxon test was used to compare bacterial counts and anti-bacterial antibodies and Student's t test was used to compare the other numerical values. The subjects were patients with (n = 34) or without (n = 956) PAD. We revealed that the PAD patients had more missing teeth (17.5 +/- 11.0), a higher rate of edentulism (18%), and higher serum inflammatory factor levels than non-PAD patients (10.9 +/- 8.7, 5%, respectively). On the other hand, there was no significant difference between hypertension, dyslipidemia, smoking status, HbA1c, bacterial antibody titers, and bacterial counts between the groups. In conclusion, we clarified that PAD patients had decreased tooth number and worsened oral and periodontal condition with enhanced systemic inflammation.
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