Journal
HEALTH PHYSICS
Volume 113, Issue 6, Pages 452-457Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HP.0000000000000720
Keywords
biological indicators; children; modeling; dose assessment; radiation risk
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Funding
- Department of Homeland Security (DHS) Science and Technology Directorate (ST) [HSHQDC-12-C-00005]
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Following a radiological terrorist attack or radiation accident, the general public may be exposed to radiation. Historically, modeling efforts have focused on radiation effects on a reference mana 70-kg, 180-cm-tall, 20- to 30-y-old malewhich does not adequately reflect radiation hazard to special populations, particularly children. This work examines the radiosensitivity of children with respect to reference man to develop a set of parameters for modeling hematopoetic acute radiation syndrome in children. This analysis was performed using animal studies and the results verified using data from medical studies. Overall, the hematopoietic system in children is much more radiosensitive than that in adults, with the LD50 for children being 56% to 91% of the LD50 of adults, depending on age.
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