4.3 Article

Testosterone is associated with insulin resistance index independently of adiposity in women with polycystic ovary syndrome

Journal

GYNECOLOGICAL ENDOCRINOLOGY
Volume 34, Issue 1, Pages 40-44

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/09513590.2017.1342793

Keywords

Insulin secretion; insulin sensitivity; inflammation polycystic ovary syndrome; adiposity; androgens

Funding

  1. Academy of Finland
  2. Sigrid Juselius Foundation
  3. Helsinki University Central Hospital
  4. Novo Nordisk Fonden [NNF16OC0021238] Funding Source: researchfish

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Objective: To study the associations between androgens, glucose homeostasis, inflammation and statin treatment in women with polycystic ovary syndrome (PCOS). Design and methods: Oral glucose tolerance tests, androgens, hs-CRP and interleukin-1 receptor antagonist (IL-1Ra) were analyzed at baseline and after 6 months of atorvastatin (20 mg/d) or placebo treatment in 27 women with PCOS. Results: Testosterone associated with insulin resistance measured with ISIMatsuda independently of BMI, age and SHBG concentrations and the full model, including IL-1Ra, hs-CRP and HDL-C, also showed independency of BMI and waist circumference (p <= .042). Free androgen index (FAI) associated with ISIMatsuda independently of adiposity (p <= .025) but in the full model with waist circumference the association was insignificant. ISIMatsuda decreased with testosterone > 1.2 nmol/l compared with lower levels at baseline (p = .043) and at six months (p = .003). Accordingly, 30-minute insulin levels were increased with moderately elevated testosterone independently of adiposity (p <= .046). Increased fasting glucose and AUC insulin associated with statin treatment independently of adiposity and the associations attenuated after adjusting for testosterone. Conclusions: Moderately elevated testosterone concentrations together with obesity-related inflammatory factors modify glucose homeostasis by increasing insulin resistance and early insulin secretion.

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