Journal
GYNECOLOGICAL ENDOCRINOLOGY
Volume 33, Issue 11, Pages 861-863Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09513590.2017.1334197
Keywords
Folic acid; vitamin B12; homocysteine; in vitro fertilization; Italy
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Italian public health authorities recommend women of childbearing age to assume a daily dose of 0.4mg of folic acid (FA) from at least one month before conception in order to reduce the risk of having children affected by neural tube defects (NTDs). In this study, folate, homocysteine and vitamin B12 serum levels were determined in 77 women entering an in vitro fertilization program. About 75% of patients had serum folate values compatible with the intake of the recommended dose of FA for at least three months, whereas only the 61% of them reached or exceeded the serum folate concentration regarded as the optimal concentration during the periconceptional period. Mean vitamin B12 serum levels and mean homocysteine plasma levels resulted in normal range in all the women with mean values of 381.22.2pg/ml and 8.48 +/- 2.2mol/l, respectively. In conclusion, only a portion of women entering an IVF program presents proper folate levels.
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