Journal
GREEN CHEMISTRY
Volume 19, Issue 4, Pages 1128-1133Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6gc03115c
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Funding
- National Natural Science Foundation of China [81421005]
- Natural Science Foundation of Jiangsu Province [BK20160743]
- 111 Project [B16046]
- Project Program of State Key Laboratory of Natural Medicines, China Pharmaceutical University [SKLNMZZYQ201602]
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In the presence of dimethyl sulfoxide (DMSO) as a mild oxidant and reaction medium, a simple and efficient protocol has been developed for the preparation of phosphinothioates via oxidative dehydro-genative phosphorylation of thiols with P(O)H compounds. Additionally, a DMSO-mediated oxidative phosphorylation of disulfides is also demonstrated. Notably, these transformations occur efficiently without the help of any transition metal or additive. These reactions are easy to conduct and can be scaled-up, and various phosphinothioates are readily obtained in moderate to excellent yields with excellent chemoselectivity and good functional-group tolerance.
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