Journal
GREEN CHEMISTRY
Volume 19, Issue 2, Pages 405-410Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6gc01668e
Keywords
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Funding
- German Federal Ministry of Education and Research (Bundesministerium fur Bildung und Forschung, BMBF) [031A184A]
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Whole-cell catalysts overexpressing two enzymes for a double reduction cascade in which aliphatic alpha-branched alpha,beta-unsaturated aldehydes are converted into Guerbet alcohols as a highly demanded class of lubricants were constructed and characterized. The reaction conditions were optimized to suppress by-product formation, achieving high conversion and selectivity. Application of methanol as a co-solvent on a 500 mL scale enabled a substrate concentration of 18.5 g L-1 obtaining 97% yield and 88% purity without further distillation. Addressing the needs of industrial processes, substrate loading was increased up to 94 g L-1 and the E-factor (environmental factor) was significantly improved compared to the original process with isolated enzymes.
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