Journal
GREEN CHEMISTRY
Volume 19, Issue 11, Pages 2687-2694Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7gc00722a
Keywords
-
Funding
- Ministerio de Economia y Competividad, Spain [CTQ2014-58664-R, RYC-2015-17705]
- European Regional Development Fund
- URV
Ask authors/readers for more resources
Supercritical carbon dioxide (scCO(2)) is a suitable medium to perform transition metal-free glycosylation reactions in the absence of volatile organic solvents (VOCs) using glycosyl halides as glycosyl donors. The methodology described here can be applied for obtaining O-glycosides in a totally green reaction, as well as orthoesters, depending on the reaction conditions. The process is much more sensitive to temperature changes than to pressure modification, with glycosyl chlorides requiring higher temperatures to be activated than glycosyl bromides. Pivaloyl groups act as good CO2-philic units and are shown to be the best choice to obtain good stereoselectivities. The relevance of the fluid nature and supercritical conditions was also evidenced.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available