Journal
GREEN CHEMISTRY
Volume 19, Issue 18, Pages 4451-4456Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7gc01903c
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Funding
- John S. Latsis Public Benefit Foundation
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Selective C-H activation is an area of growing importance in modern organic chemistry. Herein, we report our efforts in combining organocatalysis and photocatalysis for the development of a highly efficient and selective visible-light mediated protocol for the C-H activation and addition of various alcohols to a plethora of Michael acceptors, followed by a cyclization reaction leading to lactones, a repeatedly occurring motif in nature. Utilizing phenylglyoxylic acid as the photocatalyst and common household bulbs as the light source, we describe a versatile alpha-alkylation/lactonization of alcohols witha alpha,beta-unsaturated esters leading to products in excellent yields. The reaction mechanism was extensively studied.
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