Base-controlled highly selective synthesis of alkyl 1,2-bis(boronates) or 1,1,2-tris(boronates) from terminal alkynes

Transition-metal-free base-controlled highly regioselective synthesis of alkyl 1,2-bis(boronates) or 1,1,2-tris(boronates) from various terminal alkynes has been disclosed. These reactions are efficient, practical and mild with good regioselectivity, excellent functional group tolerance as well as good scalability, which provide general and complementary methods to access multi-borylated alkanes from various terminal alkynes.