Journal
GREEN CHEMISTRY
Volume 19, Issue 11, Pages 2620-2625Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7gc00615b
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Funding
- RWTH Aachen University from the Distinguished Professorship Program - Excellence Initiative of the German federal government
- RWTH Aachen University from the Distinguished Professorship Program - Excellence Initiative of the German state government
- agency EPSRC [EP/L019655/1]
- EPSRC [EP/L019655/1] Funding Source: UKRI
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Mechanochemical chemoenzymatic peptide and amide bond formation catalysed by papain was studied by ball milling. Despite the high-energy mixing experienced inside the ball mill, the biocatalyst proved stable and highly efficient to catalyse the formation of alpha, alpha- and alpha, beta-dipeptides. This strategy was further extended to the enzymatic acylation of amines by milling, and to the mechanosynthesis of a derivative of the valuable dipeptide L-alanyl-L-glutamine.
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