Journal
GREEN CHEMISTRY
Volume 19, Issue 24, Pages 5841-5845Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7gc02484c
Keywords
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Funding
- National Research Foundation (NRF) of South Africa
- Thuthuka research grant
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An efficient and practical aerobic benzylic sp(3) C-H oxidation as a key step towards the domino multicomponent synthesis of 2,4,5-trisubstituted imidazoles has been reported. This green methodology employs an inexpensive catalytic copper/oxygen system and proceeds under mild reaction conditions. A variety of substituted imidazoles are prepared in moderate to excellent yields from a-methylene ketones using this innovative methodology.
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