Journal
GREEN CHEMISTRY
Volume 19, Issue 23, Pages 5653-5658Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7gc02353g
Keywords
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Funding
- NSFC [21702117, 21776148]
- Natural Science Foundation of Shandong Province [JQ201604, ZR2016BM07, ZR2017BB005]
- Key Research and Development Program of Shandong Province [2017GSF218073]
- Qingdao Special Research Foundation of Science and Technology [16-6-2-29-nsh]
- Talents of High Level Scientific Research Foundation of Qingdao Agricultural University [6631112323, 6631115015, 6631110309]
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The pharmaceutically important tetrahydroquinoline spiro compounds were efficiently constructed via cascade SNAr/Knoevenagel condensation/[1,5]-hydride transfer/cyclization on water, featuring high atom-economy and step-economy. This water-based redox-neutral C(sp(3))-H functionalization rendered a 4-step cascade reaction successful without resorting to any catalysts.
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