Journal
GREEN CHEMISTRY
Volume 19, Issue 13, Pages 2945-2951Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7gc00977a
Keywords
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Funding
- National Natural Science Foundation of China [21672163, 81272462]
- Natural Science Foundation of Zhejiang Province [LR14B020002, LY13H300005]
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By using air as the superior oxidant, a highly atom-efficient synthesis of 2-substituted quinazolines is developed by a CsOH-mediated direct aerobic oxidative reaction of the readily available and stable 2-aminoarylmethanols and nitriles. Effectively working as the promoter in the alcohol oxidation, nitrile hydration, and cyclocondensation steps, CsOH is the best base for the reaction. A similar method can also be extended to the synthesis of substituted quinolines starting from methyl ketones instead of nitriles.
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