Journal
GLYCOCONJUGATE JOURNAL
Volume 34, Issue 3, Pages 363-376Publisher
SPRINGER
DOI: 10.1007/s10719-017-9761-z
Keywords
Proteoglycans; Glycosaminoglycans; Chondroitin sulfate; Protein-glycosaminoglycan interactions; Central nervous system; Plasticity; Perineuronal nets
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Funding
- UGA
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Chondroitin sulfate (CS) is the most abundant glycosaminoglycan (GAG) in the central nervous system (CNS) matrix. Its sulfation and epimerization patterns give rise to different forms of CS, which enables it to interact specifically and with a significant affinity with various signalling molecules in the matrix including growth factors, receptors and guidance molecules. These interactions control numerous biological and pathological processes, during development and in adulthood. In this review, we describe the specific interactions of different families of proteins involved in various physiological and cognitive mechanisms with CSs in CNS matrix. A better understanding of these interactions could promote a development of inhibitors to treat neurodegenerative diseases.
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