Journal
GLIA
Volume 66, Issue 6, Pages 1138-1159Publisher
WILEY
DOI: 10.1002/glia.23248
Keywords
in vitro; in vivo; organization level; spatio-temporal resolution
Categories
Funding
- Fondecyt [1160317]
- MINECO [SAF2016-78114-R, RTC-2015-3237-1]
- CIBERFES [CB16/10/00282]
- SP3-People-MC-ITN program [608381]
- EU BATCure [666918]
- FEDER (European regional development fund)
- Investissement d'Avenir [ANR-11-INBS-0011]
- French State in the context of the Investments for the future Program IdEx [ANR-10-IDEX, ANR-10-LABX-57]
- French State in the context of the Investments for the future Program LabEx TRAIL [ANR-10-IDEX, ANR-10-LABX-57]
- French-Swiss ANR-FNS [ANR-15-CE37-0012, 310030E-164271]
- University of Nottingham
- BBSRC [BB/L019396/1, BB/K009192/1]
- MRC [MR/L020661/1]
- Deutsche Forschungsgemeinschaft [DFG SPP 1757, SFB 894, FOR 2289]
- European Commission [H2020-FETPROACT 732344]
- Neurofibres [H2020-MSCA-ITN-722053 EU-GliaPhD]
- US National Institutes of Health [R01NS087611]
- Teva Pharmaceuticals
- Agilent Technologies
- IdEx [ANR-10-IDEX-03-02]
- National Institutes of Neurologic Disease and Stroke at the National Institutes of Health [R01 NS077773]
- University of Zurich
- Swiss National Science Foundation
- Comision Nacional de Investigacion Cientifica y Tecnologica [PB 01]
- Fondo Nacional de Desarrollo Cientifico y Tecnologico [1160317]
- Ministerio de Economia y Competitividad [SAF2016-78114-R, RTC-2015-3237-1]
- Agence Nationale de la Recherche [ANR-11-INBS-0011, ANR-10-IDEX, ANR-10-LABX-57, ANR-15-CE37-0012, ANR-10-IDEX-03-02]
- Biotechnology and Biological Sciences Research Council [BB/L019396/1, BB/K009192/1]
- Medical Research Council [MR/L020661/1]
- BBSRC [BB/L019396/1, BB/K009192/1] Funding Source: UKRI
- MRC [MR/L020661/1] Funding Source: UKRI
- Swiss National Science Foundation (SNF) [310030E-164271] Funding Source: Swiss National Science Foundation (SNF)
- Biotechnology and Biological Sciences Research Council [BB/K009192/1, BB/L019396/1] Funding Source: researchfish
- Medical Research Council [MR/L020661/1] Funding Source: researchfish
Ask authors/readers for more resources
Neuroscience is a technology-driven discipline and brain energy metabolism is no exception. Once satisfied with mapping metabolic pathways at organ level, we are now looking to learn what it is exactly that metabolic enzymes and transporters do and when, where do they reside, how are they regulated, and how do they relate to the specific functions of neurons, glial cells, and their subcellular domains and organelles, in different areas of the brain. Moreover, we aim to quantify the fluxes of metabolites within and between cells. Energy metabolism is not just a necessity for proper cell function and viability but plays specific roles in higher brain functions such as memory processing and behavior, whose mechanisms need to be understood at all hierarchical levels, from isolated proteins to whole subjects, in both health and disease. To this aim, the field takes advantage of diverse disciplines including anatomy, histology, physiology, biochemistry, bioenergetics, cellular biology, molecular biology, developmental biology, neurology, and mathematical modeling. This article presents a well-referenced synopsis of the technical side of brain energy metabolism research. Detail and jargon are avoided whenever possible and emphasis is given to comparative strengths, limitations, and weaknesses, information that is often not available in regular articles.
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