Journal
AGING CELL
Volume 14, Issue 4, Pages 701-703Publisher
WILEY
DOI: 10.1111/acel.12334
Keywords
telomeres; twins; father's age; germ line; heritability; leukocytes
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Funding
- NIH [AG030678]
- Danish Council for Independent Research-Medical Sciences
- INTERREG 4 A-program Southern Denmark-Schleswig-K.E.R.N.- European Regional Development Fund
- A.P. Moller Foundation for the Advancement of Medical Science
- National Institute for Health Research [NF-SI-0514-10027] Funding Source: researchfish
- NATIONAL INSTITUTE ON AGING [R01AG030678] Funding Source: NIH RePORTER
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Telomere length, a highly heritable trait, is longer in offspring of older fathers. This perplexing feature has been attributed to the longer telomeres in sperm of older men and it might be an epigenetic' mechanism through which paternal age plays a role in telomere length regulation in humans. Based on two independent (discovery and replication) twin studies, comprising 889 twin pairs, we show an increase in the resemblance of leukocyte telomere length between dizygotic twins of older fathers, which is not seen in monozygotic twins. This phenomenon might result from a paternal age-dependent germ stem cell selection process, whereby the selected stem cells have longer telomeres, are more homogenous with respect to telomere length, and share resistance to aging.
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