Journal
EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
Volume 26, Issue 5, Pages 1647-1651Publisher
SPRINGER
DOI: 10.1007/s40519-020-00963-y
Keywords
Amino acids; ACE2; B(0)AT1; COVID-19; Gastrointestinal disturbances; Hartnup disease
Categories
Funding
- Cariplo Foundation [1006-2016]
- Professional Dietetics (Milan, Italy)
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During the COVID-19 pandemic, clinicians have been working hard to find effective treatments for the disease, with gastrointestinal disturbances being a notable clinical presentation. Through evidence from clinical and basic research, a novel hypothesis has been proposed to improve symptoms in COVID-19 patients by increasing amino acid supplements.
Since the outbreak of COVID-19, clinicians have tried every effort to fight the disease, and multiple drugs have been proposed. However, no proven effective therapies currently exist, and different clinical phenotypes complicate the situation. In clinical practice, many severe or critically ill COVID-19 patients developed gastrointestinal (GI) disturbances, including vomiting, diarrhoea, or abdominal pain, even in the absence of cough and dyspnea. Understanding the mechanism of GI disturbances is warranted for exploring better clinical care for COVID-19 patients. With evidence collected from clinical studies on COVID-19 and basic research on a rare genetic disease (i.e., Hartnup disorder), we put forward a novel hypothesis to elaborate an effective nutritional therapy. We hypothesize that SARS-CoV-2 spike protein, binding to intestinal angiotensin-converting enzyme 2, negatively regulates the absorption of neutral amino acids, and this could explain not only the GI, but also systemic disturbances in COVID-19. Amino acid supplements could be recommended.
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