Journal
GENETICS AND MOLECULAR BIOLOGY
Volume 40, Issue 1, Pages 22-30Publisher
SOC BRASIL GENETICA
DOI: 10.1590/1678-4685-GMB-2016-0258
Keywords
RNA-binding proteins; Trypanosoma cruzi; Saccharomyces cerevisiae; gene expression regulation
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RNA-binding proteins (RBPs) have important functions in the regulation of gene expression. RBPs play key roles in post-transcriptional processes in all eukaryotes, such as splicing regulation, mRNA transport and modulation of mRNA translation and decay. RBPs assemble into different mRNA-protein complexes, which form messenger ribonucleoprotein complexes (mRNPs). Gene expression regulation in trypanosomatids occurs mainly at the post-transcriptional level and RBPs play a key role in all processes. However, the functional characterization of RBPs in Trypanosoma cruzi has been impaired due to the lack of reliable reverse genetic manipulation tools. The comparison of RBPs from Saccharomyces cerevisiae and T. cruzi might allow inferring on the function of these proteins based on the information available for the orthologous RNA-binding proteins from the S. cerevisiae model or-ganism. In this review, we discuss the role of some RBPs from T. cruzi and their homologues in regulating gene expression in yeast.
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