Journal
GENETICS
Volume 207, Issue 1, Pages 29-47Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.115.186627
Keywords
FlyBook; Drosophila melanogaster; origin activation; endocycle; differential replication; underreplication; gene amplification; rereplication
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Funding
- National Institutes of Health [GM057960, GM118098]
- Massachusetts Institute of Technology School of Science Fellowship in Cancer Research
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Proper control of DNA replication is critical to ensure genomic integrity during cell proliferation. In addition, differential regulation of the DNA replication program during development can change gene copy number to influence cell size and gene expression. Drosophila melanogaster serves as a powerful organism to study the developmental control of DNA replication in various cell cycle contexts in a variety of differentiated cell and tissue types. Additionally, Drosophila has provided several developmentally regulated replication models to dissect the molecular mechanisms that underlie replication-based copy number changes in the genome, which include differential underreplication and gene amplification. Here, we review key findings and our current understanding of the developmental control of DNA replication in the contexts of the archetypal replication program as well as of underreplication and differential gene amplification. We focus on the use of these latter two replication systems to delineate many of the molecular mechanisms that underlie the developmental control of replication initiation and fork elongation.
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