Journal
GENETICS
Volume 207, Issue 4, Pages 1423-1440Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.117.300383
Keywords
primary cilia; MAPK15; C. elegans; basal body
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Funding
- European Regional Development Fund, part of the European Union Structural Funds Programme
- National Institutes of Health [R37 GM-56223, R35 GM-22463, T32 GM-7122]
- Science Foundation Ireland [11/PI/1037]
- European Community's Seventh Framework Programme [241955]
- Programme for Research in Third Level Institutions (PRTLI)
- Science Foundation Ireland (SFI) [11/PI/1037] Funding Source: Science Foundation Ireland (SFI)
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Motile and immotile (or primary) cilia are microtubule-based structures that mediate multiple cellular functions, including the transduction of environmental cues, developmental signaling, cellular motility, and modulation of fluid flow. Although their core architectures are similar, motile and primary cilia exhibit marked structural differences that underlie distinct functional properties. However, the extent to which ciliogenesis mechanisms are shared between these different cilia types is not fully described. Here, we report that the atypical MAP kinase MAPK15 (ERK7/8), implicated in the formation of vertebrate motile cilia, also regulates the formation of primary cilia in Caenorhabditis elegans sensory neurons and human cells. We find that MAPK15 localizes to a basal body subdomain with the ciliopathy protein BBS7 and to cell-cell junctions. MAPK15 also regulates the localization of ciliary proteins involved in cilium structure, transport, and signaling. Our results describe a primary cilia-related role for this poorly studied member of the MAPK family in vivo, and indicate a broad requirement for MAPK15 in the formation of multiple ciliary classes across species.
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