Journal
AGING NEUROPSYCHOLOGY AND COGNITION
Volume 28, Issue 5, Pages 733-747Publisher
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/13825585.2020.1817306
Keywords
Aging; mild cognitive impairment; cognitive decline; cognitive disorders; cognitive function; task performance
Funding
- National Institute on Aging [R01AG036921, R01AG044007]
- National Institute of Health [R01AG036921, R01AG044007, R01NS109023]
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This study found that greater word production in semantic fluency across all time intervals predicted a reduced risk of incident MCI, while for letter fluency, greater word production only within the third time interval was significantly associated with reduced risk of incident MCI. The clinical use of within-interval performance is supported due to evidence of predictive sensitivity and ease of administration.
The current study aimed to determine whether word generation performance on individual within-task 20-second time intervals predicted conversion to Mild Cognitive Impairment (MCI) status. Longitudinal data (Mean follow-up=2.95 +/- 1.64 years) was collected from cognitively-healthy community-dwelling older adults (N=344; %female=56.1). Performance on letter and semantic fluency tasks was divided into three consecutive within-task 20-second intervals. Incident MCI status (n=50) was determined via established diagnostic case conference. Fully adjusted Cox proportional-hazards regression models revealed that greater word production on semantic fluency across all time intervals significantly predicted a reduced risk of incident MCI [0-20 seconds (HR=0.906, p=0.002), 21-40 seconds (HR=0.904, p=0.02), and 41-60 seconds (HR=0.892, p=0.017)]. Conversely, on letter fluency, greater word production within the 41-60 second time interval only was significantly associated with reduced risk of incident MCI (HR=0.886, p=0.002). Overall, the clinical use of within-interval performance is supported given evidence of predictive sensitivity and ease of administration.
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