Growth arrest-specific 2 protein family: Structure and function

Members of the growth arrest-specific 2 (GAS2) protein family consist of a putative actin-binding (CH) domain and a microtubule-binding (GAR) domain and are considered miniversions of spectraplakins. There are four members in the GAS2 family, viz. GAS2, GAS2L1, GAS2L2 and GAS2L3. Although GAS2 is defined as a family of growth arrest-specific proteins, the significant differences in the expression patterns, interaction characteristics and biological issues or diseases among the different GAS2 family members have not been systemically reviewed to date. Therefore, we summarized the available evidence on the structures and functions of GAS2 family members. This review facilitates a comprehensive molecular understanding of the involvement of the GAS2 family members in an array of biological processes, including cytoskeleton reorganization, cell cycle, apoptosis and cancer development.

Automated summary

Members of the GAS2 protein family consist of actin-binding and microtubule-binding domains, resembling miniversions of spectraplakins. Despite being classified as growth arrest-specific proteins, the distinct expression patterns, interaction characteristics, and biological roles among GAS2 family members have not been thoroughly reviewed. This review provides insights into the structures and functions of GAS2 family members and their involvement in various biological processes.