Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 31, Issue 7, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202006453
Keywords
antimicrobial; combination therapy; dendritic hybrid hydrogels; dendritic nanogels; drug delivery
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Funding
- China Scholarship Council
- Knut and Alice Wallenberg Foundation KAW [2012.0196, 2017.0300]
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Biocompatible and degradable dual-delivery gel systems based on HBDLDs were constructed via thiol-ene click chemistry, allowing tunable elasticity of the gels and co-delivery of NB and CIP. The innovative hybrid hydrogels showed promise in treating bacterial infections and as wound dressing materials with enhanced cell proliferation and biodegradability.
Biocompatible and degradable dual-delivery gel systems based on hyperbranched dendritic-linear-dendritic copolymers (HBDLDs) is herein conceptualized and accomplished via thiol-ene click chemistry. The elasticity of the hydrogels is tunable by varying the lengths of PEG (2, 6, 10 kDa) or the dry weight percentages (20, 30, 40 wt%), and are found to range from 2-14.7 kPa, comparable to human skin. The co-delivery of antibiotics is achieved, where the hydrophilic drug novobiocin sodium salt (NB) is entrapped within the hydrophilic hydrogel, while the hydrophobic antibiotic ciprofloxacin (CIP) is encapsulated within the dendritic nanogels (DNGs) with hydrophobic cores (DNGs-CIP). The DNGs-CIP with drug loading capacity of 2.83 wt% are then physically entrapped within the hybrid hydrogels through UV curing. The hybrid hydrogels enable the quick release of NB and prolonged released of CIP. In vitro cell infection assays showed that the antibiotic-loaded hybrid hydrogels are able to treat bacterial infections with significant bacterial reduction. Hybrid hydrogel band aids are fabricated and exhibited better antibacterial activity compared with commercial antimicrobial band aids. Remarkably, most hydrogels and hybrid hydrogels show enhanced human dermal cell proliferation and could be degraded into non-toxic constituents, showing great promise as wound dressing materials.
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