Journal
MOLECULAR PSYCHIATRY
Volume 26, Issue 1, Pages 134-150Publisher
SPRINGERNATURE
DOI: 10.1038/s41380-020-00925-x
Keywords
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Funding
- Alfred Deakin Postdoctoral Research Fellowship
- Multiple Sclerosis Research Australia
- Cancer Council Queensland
- Bond University - Nutrition Society of Australia
- Nutrition Research Australia
- Princess Alexandra Research Foundation - Deakin University
- Be Fit Foods
- Australian Rotary Health
- Deakin University Postgraduate Industry Research Scholarship
- NHMRC Senior Principal Research Fellowship [1059660, 1156072]
- NIH, Cooperative Research Centre, Simons Autism Foundation
- Cancer Council of Victoria
- Stanley Medical Research Foundation
- Medical Benefits Fund
- National Health and Medical Research Council, Medical Research Futures Fund, Beyond Blue
- A2 milk company, Meat and Livestock Board, Woolworths, Avant
- Harry Windsor Foundation
- Bioadvantex
- Lundbeck Merck
- Pfizer
- Servier
- Australian Research Council, National Health and Medical Research Council
- ChemGenex Pharmaceuticals
- Johnson & Johnson - Wellcome Trust strategy award
- Alzheimer's Disease (NIMA) Consortium [104025]
- GlaxoSmithKline
- Pfizer - UK Medical Research Council [MR/L014815/1, MR/J002739/1, MR/N029488/1]
- European Commission [SC1-BHC-01-2019]
- National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London [2017-2025]
- Irish Research Council postdoctoral fellowship
- Science Foundation Ireland [SFI/12/RC/2273-P2, 15/JPHDHL/3270]
- Joint Programming Initiative HEALTHMARK: Metabolic HEALTH through nutrition,microbiota [16/ERAHDHL/3362]
- Swiss National Foundation Sinergia
- Irish Research Council
- European Union
- Irish Research Council Postgraduate Scholarship [GOIPG/2019/3198, GOIPG/2018/2560]
- Health Research Board (HRB) [ILP-POR-2017-013]
- Saks Kavanaugh Foundation
- Mead Johnson
- 4D Pharma
- Nutricia
- Alkermes
- Nestle
- Roche
- Ordesa and Neuraxpharm - Science Foundation Ireland (SFI) [12/RC/2273-P2]
- Irish Health Research Board (HRB) [ILP-POR-2017-013]
- University of Manchester Presidential Fellowship [P123958]
- UK Research and Innovation Future Leaders Fellowship [MR/T021780/1]
- NICM-Blackmores Institute Fellowship - Australian Research Council [DP190103081]
- National Health and Medical Research Council [APP114333, APP1079102]
- Waterloo Foundation
- Trajan Scientific and Medical [MOST 106-2314-B-039-027-MY3, 108-2320-B-039-048, 108-2813-C-039-133-B, 108-2314-B-039-016]
- Ministry of Science and Technology, Taiwan [NHRI-EX108-10528NI]
- National Health Research Institutes, Taiwan [MYRG2018-00242-ICMS]
- University of Macau, China [CMRC-CMA-3]
- Higher Education Sprout Project by the Ministry of Education (MOE), Taiwan [CMU108-SR-106]
- China Medical University, Taichung, Taiwan [CRS-108-048, DMR-108-216, DMR-109-102]
- China Medical University Hospital, Taichung, Taiwan
- Astra Zeneca
- Lundbeck
- Eli Lilly
- Merck
- Otsuka
- Excelsior Biopharma
- Massachusetts General Hospital Psychiatry Academy
- PeerPoint Medical Education Institute, LLC
- MGH Clinical Trials Network and Institute (CTNI)
- NIMH - NINDS of National Institute of Health
- National Sciences and Engineering Research Council of Canada (NSERC)
- Ontario Brain Institute
- Ontario Government
- Fonds Baillet Latour (Grant for Medical Research)
- Fonds de la Recherche Scientifique (FNRS) [FRFS-WELBIO: WELBIO-CR-2019C-02R]
- ERC Starting Grant [336452-ENIGMO]
- Medical Research Council UK [MR/N030087/1, MR/S00484X/1]
- Network of Centres of Excellence in Neurodegeneration (COEN)
- CD investments VSL pharmaceuticals - Alfred Deakin Postdoctoral Research Fellowship
- Centre of Excellence for Neurodegenerative disorders
- Future Leader Fellowship [101160]
- Heart Foundation Australia and Wilson Foundation
- National Health & Medical Research Council
- Australian Research Council
- Meat and Livestock Australia
- Brain and Behaviour Research Institute
- National Health and Medical Research Council (NHMRC)
- Ian Potter Foundation
- Woolworths Limited
- Pharmavite
- MRC [MR/N029488/1, G108/603] Funding Source: UKRI
- Health Research Board (HRB) [ILP-POR-2017-013] Funding Source: Health Research Board (HRB)
Ask authors/readers for more resources
Nutritional psychiatry research suggests that healthy dietary patterns may play a role in depression onset and symptom management. The mechanisms of action are complex, multifaceted, and interact with each other, not restricted to any single biological pathway.
The field of nutritional psychiatry has generated observational and efficacy data supporting a role for healthy dietary patterns in depression onset and symptom management. To guide future clinical trials and targeted dietary therapies, this review provides an overview of what is currently known regarding underlying mechanisms of action by which diet may influence mental and brain health. The mechanisms of action associating diet with health outcomes are complex, multifaceted, interacting, and not restricted to any one biological pathway. Numerous pathways were identified through which diet could plausibly affect mental health. These include modulation of pathways involved in inflammation, oxidative stress, epigenetics, mitochondrial dysfunction, the gut microbiota, tryptophan-kynurenine metabolism, the HPA axis, neurogenesis and BDNF, epigenetics, and obesity. However, the nascent nature of the nutritional psychiatry field to date means that the existing literature identified in this review is largely comprised of preclinical animal studies. To fully identify and elucidate complex mechanisms of action, intervention studies that assess markers related to these pathways within clinically diagnosed human populations are needed.
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