Journal
ARCHIV DER PHARMAZIE
Volume 354, Issue 3, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ardp.202000284
Keywords
anticancer; coumarin; cytotoxicity; molecular docking; triazole
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This study reported the synthesis of coumarin derivatives containing the triazole ring and investigated their anticancer activities, showing strong cytotoxic effects against various cancer cell lines. In silico studies were also conducted to explore the binding interactions of the molecules.
The synthesis, docking study, and investigation of the anticancer activities of some coumarin derivatives containing the triazole ring are reported in this study. The newly synthesized compounds were screened for their in vitro anticancer activity against the cell lines CRL5807 (human bronchioalveolar carcinoma), CRL5826 (human squamous cell carcinoma), MDA-MB231 (human breast cancer cells), HTB177 (human lung cancer), PC-3 (human prostate adenocarcinoma), PANC-1 (human pancreatic cancer cells), used as cancer cells, and CCD34Lu (normal human lung fibroblasts), used as a healthy cell line. Cytotoxicity effects of the samples were determined by the MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) assay. In silico studies were also performed to explore the binding interactions of the molecules.
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